The World’s Most Genetically Modified Person

BioViva Science
9 min readMar 14, 2024


Science is where curiosity, ambition, and innovation meet.

Liz Parrish, founder and CEO of BioViva Science, is spearheading a campaign against the greatest killer on the planet. She stands, unvexed by criticism and convention, in the vanguard of bringing tomorrow’s treatments to those who need them today.

Her journey began when her son was diagnosed with type-1 diabetes.

She recounts, “I was not a longevity person. I wasn’t trying to live forever. I was trying to translate cures to kids. And by pounding the pavement, and looking and seeing what was happening in research, I realized we can help these kids live longer and find cures while helping billions of people live longer.”

This culminated in BioViva, its patent-pending gene therapies, and its CMV gene delivery technology.

Joining a long list of illustrious mavericks in medicine, Liz took matters into her own hands when she became the first person to take gene therapy to treat biological aging.

In fact, she took two gene therapies in 2015: follistatin and telomerase. The former to address sarcopenia (age-related muscular atrophy) and the latter to lengthen her telomeres.

Parrish states, “Today, we are living longer than ever–which is great. But the caveat is that this means we are also in ill-health longer than ever…Biological aging is the biggest killer on the planet.”

Not only does this impact individuals, but the effects of chronic illness ripple: from family members who have to watch their loved ones struggle to already strained healthcare agencies buckling under the burden of aging populations.

Parrish also took Klotho and PGC-1α gene therapies in 2020.

Klotho, the queen of anti-aging proteins, is pivotal to maintaining mineral balance, warding off vascular calcification, and protecting our hearts. Reduced levels contribute to accelerated aging and kidney disease. It also shows tremendous promise in neuroprotection and cognitive enhancement.

“Like telomerase, Klotho is an amazingly versatile protein. Of any single gene to date, it is mostly closely associated with IQ; my IQ increased by 10 points after taking Klotho.” Parrish said, “…what we’re aiming for are therapeutics that work on many systems simultaneously.”

PGC-1α is the master of mitochondrial biogenesis–it tells our cells to make more mitochondria.

As the powerhouses of our cells, mitochondria are paramount. Dysfunction and degeneration are linked to fatigue, mood swings, aging skin, and cardiovascular diseases.

By stimulating the creation of new mitochondria, PGC-1α spreads the workload: enhancing cellular efficiency, reducing oxidative stress, and promoting healthier aging.

This is vital for weight management, regulating inflammation, and staving off neurodegenerative disorders.

Liz’s results speak for themselves.

Her C-reactive protein levels are extremely low, an excellent indicator of reduced inflammation. Her post-treatment blood glucose control is exemplary.

This is partially due to the follistatin gene therapy and an increase in muscle mass. The MRI below shows this has occurred alongside a reduction in marbling (fat) in her thighs. This enhancement is more than cosmetic; it has lastingly uplifted her metabolic health.

Before treatment her age — as measured by her telomere length — was 62. She was 45.

Now nearly nine years later, according to independent tests from multiple labs, her telomeres are longer than a healthy 25-year-old’s. No adverse side-effects have been observed (Sewell, 2022).

In animal models, telomere restoration consistently improves healthspans. More recently, telomerase delivered with BioViva’s proprietary CMV platform extended the median lifespans of mice by 41.4% (de Jesus, 2011; Jaijyan, 2022).

In a 2022 presentation, Parrish put BioViva’s mission into perspective, “[BioViva’s] job is to take the big risk, to get out there, because the most important thing is that this technology gets to you. I am fighting for the future…your genetic rights.”

Parrish wrote in a recent journal article, “My goal is to streamline the regulatory approval process of gene therapies with early patient access and subsequent data analysis. I founded BioViva in 2015 to make better therapeutics and analyze data from clinics around the world.”

Despite pushback, Liz Parrish continues to fight for our brilliant future. She does this through BioViva and initiatives like Best Choice Medicine.

Best Choice Medicine may be instrumental in delivering better therapeutics to those who need them. Proposed by William Andrews and Liz Parrish, BCM is a model for expanding patient access.

Best Choice Medicine is designed to improve safety standards while reducing red tape to get new therapeutics to those who need them when they need them.

BCM is a compassionate and patient-centered approach. These terms are bandied about, but what is more compassionate than giving someone a chance at life, or a chance to truly live again?

Liz’s inspiring ethos is reminiscent of the words of Renaissance Humanist, Pico della Mirandola, “Let a holy ambition enter our souls; let us not be content with mediocrity, but rather strive after the highest and expend all our strength in achieving it…”

And BioViva continues to strive for a better tomorrow.

Authored by Adam Alonzi and Ryan Hall

Adam is a writer, independent researcher, award-winning author, and video maker. He is the Marketing Director for BioViva Science. Visit for more.

Ryan is an independent writer, and an avid enthusiast of emerging technologies.

He received his University education at Northern Michigan University, as a history major, where he was inducted into the Phi Beta Kappa Society for academic excellence. While in Michigan, he also trained as an athlete at the United States Olympic Education Center, where he achieved the status of a multiple-time University All-American in Greco-Roman wrestling.

References and Suggested Reading

Anderson, G., and Michael Maes. “Mitochondria and immunity in chronic fatigue syndrome.” Progress in Neuro-Psychopharmacology and Biological Psychiatry 103 (2020): 109976.

Beal, M. Flint. “Mitochondria, oxidative damage, and inflammation in Parkinson’s disease.” Annals of the New York Academy of Sciences 991.1 (2003): 120–131.

Bernardes de Jesus, Bruno, et al. “Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer.” EMBO molecular medicine 4.8 (2012): 691–704.

Bian, Ao, et al. “Klotho, stem cells, and aging.” Clinical Interventions in Aging (2015): 1233–1243.

Blackburn, Elizabeth, and Elissa Epel. The telomere effect: A revolutionary approach to living younger, healthier, longer. Hachette UK, 2017.

Bournat, Juan C., and Chester W. Brown. “Mitochondrial dysfunction in obesity.” Current opinion in endocrinology, diabetes, and obesity 17.5 (2010): 446.

Butcher, Joshua T., et al. “Increased muscle mass protects against hypertension and renal injury in obesity.” Journal of the American Heart Association 7.16 (2018): e009358.

Castner, Stacy A., et al. “Longevity factor klotho enhances cognition in aged nonhuman primates.” Nature Aging (2023): 1–7.

Daghlas, Iyas, Malik Nassan, and Dipender Gill. “Genetically proxied lean mass and risk of Alzheimer’s disease: mendelian randomisation study.” BMJ medicine 2.1 (2023).

de Jesus, Bruno Bernardes, et al. “The telomerase activator TA‐65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence.” Aging cell 10.4 (2011): 604–621.

Dubal, Dena B., et al. “Life extension factor klotho enhances cognition.” Cell reports 7.4 (2014): 1065–1076.

Dubal, D. B., et al. “Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice.” Journal of Neuroscience, 35(6), 2358–2371.

Dubal, D. B., et al. (2015). “Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice.” Journal of Neuroscience, 35(6), 2358–2371.

Filler, Kristin, et al. “Association of mitochondrial dysfunction and fatigue: a review of the literature.” BBA clinical 1 (2014): 12–23.

Franco, Marcella Liciani, Stephany Beyerstedt, and Érika Bevilaqua Rangel. “Klotho and mesenchymal stem cells: a review on cell and gene therapy for chronic kidney disease and acute kidney disease.” Pharmaceutics 14.1 (2021): 11.

Gutierrez-Salmean, Gabriela, et al. “Effects of (−)-epicatechin on molecular modulators of skeletal muscle growth and differentiation.” The Journal of nutritional biochemistry 25.1 (2014): 91–94.

Handschin C. The biology of PGC-1α and its therapeutic potential. Trends Pharmacol Sci. 2009 Jun;30(6):322–9.

Hartmann, Celina, and Anissa Kempf. “Mitochondrial control of sleep.” Current Opinion in Neurobiology 81 (2023): 102733.

Jaijyan, Dabbu Kumar, et al. “New intranasal and injectable gene therapy for healthy life extension.” Proceedings of the National Academy of Sciences 119.20 (2022): e2121499119.

Jürimäe, Jaak, et al. “Follistatin Is Associated with Bone Mineral Density in Lean Adolescent Girls with Increased Physical Activity.” Children 10.7 (2023): 1226.

Kang, Chounghun, and Li Li Ji. “Role of PGC-1α signaling in skeletal muscle health and disease.” Annals of the New York Academy of Sciences 1271.1 (2012): 110.

Kawarazaki, W., et al. (2020) Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency. Journal of Clinical Investigation.

Kirk B, Feehan J, Lombardi G, Duque G. Muscle, Bone, and Fat Crosstalk: the Biological Role of Myokines, Osteokines, and Adipokines. Curr Osteoporos Rep. 2020 Aug;18(4):388–400.

Ko, Byung-Joon, et al. “Relationship between low relative muscle mass and coronary artery calcification in healthy adults.” Arteriosclerosis, thrombosis, and vascular biology 36.5 (2016): 1016–1021.

Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, et al. (November 1997). “Mutation of the mouse klotho gene leads to a syndrome resembling ageing”. Nature.

Kuro-o, Makoto. “Klotho and the aging process.” The Korean journal of internal medicine 26.2 (2011): 113.

Lawrence, Grace MEP, Caroline L. Holley, and Kate Schroder. “Parkinson’s disease: connecting mitochondria to inflammasomes.” Trends in Immunology 43.11 (2022): 877–885.

Lee, Jaeho, et al. “Association between serum klotho levels and cardiovascular disease risk factors in older adults.” BMC cardiovascular disorders 22.1 (2022): 442.

Lee, Se-Jin. “Quadrupling muscle mass in mice by targeting TGF-ß signaling pathways.” PloS one 2.8 (2007): e789.

Li, L., Liu, W., Mao, Q., Zhou, D., Ai, K., Zheng, W., … & Zhao, X. (2022). Klotho Ameliorates Vascular Calcification via Promoting Autophagy. Oxidative Medicine and Cellular Longevity, 2022.

Mendell, Jerry R., et al. “Gene therapy for muscular dystrophy: lessons learned and path forward.” Neuroscience letters 527.2 (2012): 90–99.

Mendell, Jerry R., et al. “A phase 1/2a follistatin gene therapy trial for becker muscular dystrophy.” Molecular Therapy 23.1 (2015): 192–201.

Missiroli, Sonia, et al. “The role of mitochondria in inflammation: from cancer to neurodegenerative disorders.” Journal of clinical medicine 9.3 (2020): 740.

Morley, John E., et al. “Sarcopenia.” Journal of Laboratory and Clinical Medicine

137.4 (2001): 231–243.

Muñoz-Lorente, Miguel A., Alba C. Cano-Martin, and Maria A. Blasco. “Mice with hyper-long telomeres show less metabolic aging and longer lifespans.” Nature communications 10.1 (2019): 4723.

Ochi, Masayuki, et al. “Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men.” Atherosclerosis 212.1 (2010): 327–332.

Patella S, Phillips DJ, Tchongue J, de Kretser DM, Sievert W. Follistatin attenuates early liver fibrosis: effects on hepatic stellate cell activation and hepatocyte apoptosis. Am J Physiol Gastrointest Liver Physiol. 2006 Jan;290(1):G137–44.

Picard, Martin, and Bruce S. McEwen. “Mitochondria impact brain function and cognition.” Proceedings of the National Academy of Sciences 111.1 (2014): 7–8.

Rocha, Milagros, et al. “Mitochondria and T2D: role of autophagy, ER stress, and inflammasome.” Trends in Endocrinology & Metabolism 31.10 (2020): 725–741.

Rossiello, Francesca, et al. “Telomere dysfunction in ageing and age-related diseases.” Nature cell biology 24.2 (2022): 135–147.

Ruscica, Massimiliano, et al. “Side effects of statins: from pathophysiology and epidemiology to diagnostic and therapeutic implications.” Cardiovascular Research 118.17 (2022): 3288–3304.

Sewell, P. E., and D. Ediriweera. “Systemic Human Htert Aav Gene Transfer Therapy And The Effect On Telomere Length And Biological Age, A Case Report.” J Regen Biol Med 4.2 (2022): 1–8.

Smith, Rosamund C., and Boris K. Lin. “Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disorders.” Current opinion in supportive and palliative care 7.4 (2013): 352.

Tahmi, Mouna, Priya Palta, and José A. Luchsinger. “Metabolic syndrome and cognitive function.” Current Cardiology Reports 23 (2021): 1–20.

Tang, Ruhang, et al. “Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet–induced obesity.” Science Advances 6.19 (2020): eaaz7492.

Vernochet, Cecile, and C. Ronald Kahn. “Mitochondria, obesity and aging.” Aging (Albany NY) 4.12 (2012): 859.

Wang, Jia, et al. “A Role for Pgc-1α in the Control of Abnormal Mitochondrial Dynamics in Alzheimer’s Disease.” Cells 11.18 (2022): 2849.

Ziering, Craig, et al. “Hair Regrowth Following a Wnt-and Follistatin-Containing Treatment: Safety and Efficacy in.” J Drugs Dermatol 10.11 (2011): 1308–1312.

Zhang, Zilong, et al. “The association between serum soluble Klotho and chronic kidney disease among us adults ages 40 to 79 years: Cross-sectional study.” Frontiers in Public Health 10 (2022): 995314.



BioViva Science

BioViva Science is a gene therapy company that treats aging as a disease.